![]() As such, it is not different from Southern blot or Northern blot with the major exception that it allows expression profiling of the entire human genome in a single hybridization experiment.Īpplying genomics to the field of ion channels, a collection of functionally connected proteins, has already provided important information on how their transcripts are regionally expressed, and on how they are regulated by drugs or diseases in the context of a well-established cellular function. At its core, the DNA microarray utilizes a unique feature of DNA known as complementary hybridization. Expression genomics has emerged from a recently invented technology, gene chip or DNA microarray, which allows the study of the expression of thousands of genes at once. Turning on or turning off a gene at a different time or in a different place is an adaptive and coordinated response of the organism to a novel physiological or pathological environment. Functional or physiological genomics aims to link transcript expression with function. Expression genomics describes the investigation of transcription in a whole-genome manner and includes the investigation of gene regulation. The developing field of genomics is based on our capacity to obtain large comprehensive data sets on genes (wet laboratory investigation) and to analyze computationally this information (dry laboratory investigation) searching for subtle relations between genes. They have thus reached their quest for understanding the system with a knowable core of information. Cellular electrophysiologists are now informed of the ensemble of ion channel proteins, which interplay to create the electrical activity, a central function in excitable cells. IntroductionĬompletion of the sequencing of various genomes including human and mouse has resulted in the elucidation of the complete repertoire of ion channel genes. Ion channel expression, DNA microarrays, Molecular remodeling, Arrhythmias 1. ![]()
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